Author(s)

Mohamed Lamine Diallo^1*, Emmanuel Camara², Mamadou Moustapha Diop², Mamadou Cire Barry³, Fatoumata Binta Diallo², Aissata Barry², Saliou Bellanrcisse Diallo², Narcisse Idohou¹, Ganin Paul Ulrich N’dri N’gotta¹, Mamdy Dramé⁴, Telly Sy⁵, Mohamed Lamine Kaba⁶

¹Paediatric Emergency, Donka National Hospital, Conakry, Guinea.
²Paediatrics Department, Donka National Hospital, Conakry, Guinea.
³Department of Paediatrics, Hôpital National Ignace Deen, Conakry, Guinea.
⁴Centre SOS Drépano-Guinée, Conakry, Guinea.
⁵Department of Gynaecology and Obstetrics, Hôpital National Ignace Deen, Conakry, Guinea.
⁶Haemodialysis Department, Donka National Hospital, Conakry, Guinea.

Introduction: Our study focused on the evaluation of renal function in children with sickle cell disease compared to children without sickle cell disease at the pediatric emergency unit of the Donka National Hospital and SOS Drepano-Guinea center. Patients and Methods: This was a cross-sectional descriptive and analytical study lasting 3 months (October 1 to December 31, 2020). Were included, all sickle cell and non-sickle cell children aged 0 to 15 received on an outpatient basis and had undergone an exploration of renal function (serum creatinine and urine dipstick). Results: We performed the urine dipstick and serum creatinine in 75 children, 45 of whom were sickle cell and 30 were not sickle cell. 27 of our patients or 36% had a reduction in GFR, among them 9 or 20% were sickle cell and 18 or 60% were not sickle cell. The most affected age group was 5 to 9 years in sickle cell (66.7%) and non-sickle cell (38.9%). In sickle cell patients, 9 cases (100%) had mild renal failure (IRL). Non-sickle cell patients, had 14 cases or 77.8% of IRL and 4 cases (22.2%) of moderate IR. Sickle cell disease and antibiotics which had the respective p-value (0.01); (0.02), were statistically significant with the onset of renal failure. Conclusion: Several factors including sickle cell anemia and antibiotics are believed to be involved in lowering GFR. It would be essential to detect early the children received in consultation.

Flow, Filtration, Glomerular, Child, Sickle Cell Disease

Diallo, M. , Camara, E. , Diop, M. , Barry, M. , Diallo, F. , Barry, A. , Diallo, S. , Idohou, N. , N’gotta, G. , Dramé, M. , Sy, T. and Kaba, M. (2023) Glomerular Filtration Rate of Children with Sickle Cell Disease Compared to Non-Sickle Cell Patients in Donka Pediatric Emergencies and SOS Drepano-Guinea Center. Open Journal of Pediatrics, 13, 562-567. doi: 10.4236/ojped.2023.134063.