Author(s)

Jose Luis Siller-Nava¹, Adrian Espejel-Guzman², Javier Serrano-Roman¹, Aldo Cabello-Ganem¹, Alexis D. Aparicio Ortiz¹, Nilda Espinola-Zavaleta^1,3*

¹Department of Nuclear Cardiology, National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico.
²Mexican Social Security Institute, IMSS, Mexico City, Mexico.
³Department of Echocardiography, ABC Medical Center I.A.P., Mexico City, Mexico.

Background: Cardiac toxicity is currently defined as a symptomatic decrease in Left Ventricular Ejection Fraction (LVEF) of more than 5% or an asymptomatic decrease of at least 10% to a value of under 50% in repeated evaluations on conventional transthoracic echocardiogram (TTE), as well as a Global Longitudinal Strain (GLS) value < -18% or a relative reduction of 15% from baseline in any of the follow-up 2D-speckle tracking echocardiogram. Aims: To highlight using GLS rather than modified Simpson 2D-LVEF for the evaluation of long-term cardiotoxicity. Case Presentation: The case concerns a 73-year-old female patient with a history of breast cancer chemotherapy and anthracyclines-based therapy who presented symptoms of late cardiac toxicity related to the chemotherapeutic treatment. In the following years, the patient remained asymptomatic with a 2D-LVEF of 48%, dilation of the left atrium was found, and the reservoir phase strain was severely decreased. Conclusion: The preferred method for evaluating cardiovascular complications associated with chemotherapy is the TTE, which is performed prior to the start of treatment, during therapy, and in the follow-up. Myocardial deformation as a predictor of cardiotoxicity allows the identification of subclinical heart failure.

Cardiotoxicity, Breast Cancer, Global Longitudinal Strain, Left Ventricular Ejection Fraction, Heart Failure

Siller-Nava, J. , Espejel-Guzman, A. , Serrano-Roman, J. , Cabello-Ganem, A. , Ortiz, A. and Espinola-Zavaleta, N. (2023) Long Term Follow-Up of Cardiotoxicity in Breast Cancer Treatment: A Case Report. World Journal of Cardiovascular Diseases, 13, 130-137. doi: 10.4236/wjcd.2023.133011.