Results of the Management of Gastrointestinal Stromal Tumors (GIST): About 6 Cases at the Vichy Hospital Center (France) ()
ABSTRACT
The aim of our study was to analyze the results of surgical management of
gastrointestinal stromal tumors (GIST) at the Vichy Hospital Center. Methodology:
Between 2010 and 2020, the data of 6 patients operated at the Vichy Hospital
Center for GIST were analyzed. The parameters studied were: age, sex,
antecedents, discovery circumstances, imagery, surgical procedure,
anatomopathological data, the follow-up and the morbidity-mortality. Results:
There were 5 men and one woman with an average age of 72.16 years [58 - 80
years]. The average time of evolution was 8 months (0 - 14 months). The
diagnosis was fortuitous in 2 cases. Atypical abdominal pain was the main
symptom in 3 cases. One case was received in a clinical picture of peritoneal
irritation syndrome. Echo-endoscopy with biopsy specimen histology made it
possible to make the diagnosis in 5 cases and the surgical specimen in 1 case.
The fusiform type was the predominant histological form. The stomach was the most
common location. The average size of GISTs was 7.3 × 4 cm with a positive C Kit
in all patients. Neoadjuvant chemotherapy was performed on one
patient. Surgery was curative and was done laparoscopically on 4 patients.
Adjuvant chemotherapy based on Imatinib at a rate of 400 mg/d in 3 patients was
initiated. One patient presented a fistula of the esophagus-jejunal anastomosis
on D6 post operation controlled by a drainage and an antibiotic therapy.
Mortality was zero. During the surgery, all of the patients were followed up with
surgeon, oncologist. Conclusion: GISTs are the most common mesenchymal
tumors of the digestive tract with a preferential gastric location.
Laparoscopic surgery, with advances in molecular biology and the introduction
of targeted therapy has improved the management of these tumors in terms of morbidity and
mortality.
Share and Cite:
Sow, O. , Fetche, N. , Clarisse, V. , Bautrand, A. , Anusca, A. and Perrot, L. (2022) Results of the Management of Gastrointestinal Stromal Tumors (GIST): About 6 Cases at the Vichy Hospital Center (France).
Journal of Cancer Therapy,
13, 397-404. doi:
10.4236/jct.2022.137034.
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