Clostridium difficile Toxin B: Insights into Its Target Genes - Open Journal of Applied Sciences

OJAppS > Vol.12 No.3, March 2022

Open Journal of Applied Sciences

Volume 12, Issue 3 (March 2022)

ISSN Print: 2165-3917 ISSN Online: 2165-3925

Google-based Impact Factor: 0.92 Citations h5-index & Ranking

Clostridium difficile Toxin B: Insights into Its Target Genes ()

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DOI: 10.4236/ojapps.2022.123026 140 Downloads 907 Views Citations

Author(s)

Junyi Hu, Yunjie Shan, Huan Yang^*

Affiliation(s)

Xuzhou Key Laboratory of Laboratory Diagnostics, School of Medical Technology, Xuzhou Medical University, Xuzhou, China.

ABSTRACT

Clostridium difficile is a grossly Gram-positive anaerobic bacterium that has been a key factor in inducing imbalances in the gut microbiota in recent years, leading to intestinal-associated inflammation. The main pathogenic toxins of Clostridium difficile are toxin A (TcdA) and toxin B (TcdB). TcdB is the main pathogenic factor of Clostridium difficile infection. This review revealed the pathogenic mechanism of Clostridium difficile toxin B, expounded the impact of Clostridium difficile on the intestinal system, and predicted the genes on which TcdB may act, thereby providing a new therapeutic target for Clostridium difficile infection, offering theoretical basis and new strategies for clinical prevention and control.

KEYWORDS

Clostridium difficile Infection, TcdB, Gene Regulation

Share and Cite:

Hu, J. , Shan, Y. and Yang, H. (2022) Clostridium difficile Toxin B: Insights into Its Target Genes. Open Journal of Applied Sciences, 12, 368-386. doi: 10.4236/ojapps.2022.123026.

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