Distance and open education and vocational education are the two main ways of popularization of higher education and cultivation of applied talents in higher education. At present, under the background of “Internet+”, distance and open education and vocational education in China are in the stage of mutual integration. The integration of the two types of education is not only conducive to the construction of the “flyover” of lifelong education in China, but also conducive to the construction of resource sharing system, and more conducive to the adjustment, optimization and combination of educational structure and layout, so as to enhance the overall function of education, extend the educational chain and expand the educational space. This paper explores the integration path of distance and open education and vocational education from the aspects of culture, teaching methods, support services and system and mechanism.