Objective: To analyze the problems of protection COVID-19 asymptomatic infected patients, so as to ensure the safety of medical staff working in the epidemic and avoid the second outbreak. Methods: Through the analysis of main symptoms of the COVID-19 asymptomatic infected patients. Know the problems that if it is contagious, infectious strength, and the infection route etc. And take some measures such as launching medical observation for the close contacts of COVID-19 patients, investigating into epidemiology of cluster epidemic, active detection of exposed populations during the process of tracing the source of infection patients etc. to find asymptomatic infected patients. The prevention and control of asymptomatic infected persons should be strengthened by further improving the prevention and control program, increasing screening and monitoring, strengthening management and treatment, and strengthening mass prevention and control. Results: Through this method, COVID-19 asymptomatic infected patients can be detected as early as possible, and its effective prevention and control. Conclusion: The analysis of the protection problem of COVID-19 asymptomatic infector has important guiding significance to the protection of medical staff and individuals in the epidemic treatment.