Author(s)

Yiwen Xu^1,2, Weijun Hong¹, Gang Wu³, Weiling Li¹, Chunqiang Xu¹, Xiaofei Hu¹, Meixian Zhang⁴, Huihui Xu⁵, En Wang¹, Shaofa Ke¹, Xiaoping Jin^1*

¹Department of Neurology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
²The First Clinical Medical College, Wenzhou Medical University, Wenzhou, China.
³Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
⁴Public Experiment Center, Medical Research Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
⁵Laboratory of Gynecologic Oncology, Medical Research Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.

Objective: Coronavirus disease 2019 (COVID-19) spread throughout the world and caused hundreds of thousands of infected people to death. However, the pathogenesis of severe acute respiratory syndrome coronavirus-2 (SARS COV-2) is poorly understood. The objective of this study is to retrospectively explore the pathogenesis of COVID-19 from clinical laboratory findings, taking disease progression into account. Methods: A single-centered, retrospective study was carried out, which included moderate (n = 76) and severe COVID-19 cases (n = 22). The difference of laboratory findings from blood routine examination and hepatorenal function test were retrospectively evaluated between the state of moderate and severe. The disease progression was indicated by oxygenation index. Results: Age is a risk factor for disease progression from moderate to severe. Lymphocytopenia, neutrophilia, liver and kidney function decreasement occurred in severe patients on admission, compared with moderate patients. Lymphocytopenia and neutrophilia deteriorated at the lowest oxygenation index timepoint in the severe patients. And the oxygenation index was associated with ratio of lymphocyte and neutrophil in COVID-19 patients. Conclusions: Lymphocytopenia and neutrophilia, which deteriorate in the progression of severe patients, are the main pathogenesis of COVID-19. More measures need to be taken to control lymphocytopenia and neutrophilia in severe COVID-19. Oxygenation index presented potentiality as predictor on the progression of COVID-19.

COVID-19, Oxygenation Index, Lymphocytopenia, Neutrophilia, Glucocorticoids

Xu, Y. , Hong, W. , Wu, G. , Li, W. , Xu, C. , Hu, X. , Zhang, M. , Xu, H. , Wang, E. , Ke, S. and Jin, X. (2020) Lymphocytopenia and Neutrophilia Deteriorate at the Lowest Oxygenation Index Timepoint in COVID-19 Patient. International Journal of Clinical Medicine, 11, 810-822. doi: 10.4236/ijcm.2020.1112060.