Author(s)

Saharé Fongoro^1,2, Seydou Sy^1,2*, Magara Samaké^2,3, Hamadoun Yattara^1,2, Moctar Coulibaly⁴, Aboubacar Sidiki Fofana¹, Brahima Dégoga¹, Atabième Kodio¹, Eyram Yoan Makafui Amekoudi¹, Djénèba Diallo^1,2, Djénéba Maiga⁵, Aboudou M. Dolo⁵, Moustapha Tangara^1,2, Nouhoum Coulibaly¹, Kalilou Coulibaly⁶, Ibrahima Koné⁶

¹Nephrology and Haemodialysis Department of the University Teaching Hospital of Point-G, Bamako, Mali.
²Faculty of Medicine of Bamako, Bamako, Mali.
³Nephrology Unit of the Fousseyni DAOU Hospital in Kayes, Kayes, Mali.
⁴Nephrology Unit of the Mali GAVARDO Hospital, Bamako, Mali.
⁵Nephrology Unit of Sikasso Hospital, Sikasso, Mali.
⁶Nephrology Unit of Somino DOLO Hospital in Mopti, Mopti, Mali.

Context: The coexistence in the same patient of a mixed connectivitis or Sharp’s syndrome is a rare eventuality. Objective: To underline the presence of this mixed connectivitis in our practice, whose prevalence remains unknown, particularly in Africa and more precisely in Mali. Case Presentations: We report two cases of Sharp’s syndrome in a 48-year-old man and a 40-year-old woman with impaired renal function. The picture achieved associated massive proteinuria, hypoalbuminemia, moderate renal failure and edematous syndrome in men. In women, the picture was associated with accelerated to malignant hypertension and severe renal failure. There were no osteoarticular manifestations and the diagnosis of Sharp’s syndrome was based on the presence of high levels of antibodies to U1RNP. Therapeutic management has been that of predominantly associated connective tissue disease (systemic lupus erythematosus). Conclusion: Mixed connectivitis or Sharp’s syndrome is increasingly recognized as a separate entity thanks to advances in molecular biology. Its prevalence is low in sub-Saharan African countries with renal disease that manifests itself as proteinuria or nephrotic syndrome associated with microscopic hematuria, renal failure, and hypertension. This renal impairment is more likely to occur in severe forms of the disease.

Sharp Syndrome/Mixed Connectivitis, Renal Failure, Mali

Fongoro, S. , Sy, S. , Samaké, M. , Yattara, H. , Coulibaly, M. , Fofana, A. , Dégoga, B. , Kodio, A. , Amekoudi, E. , Diallo, D. , Maiga, D. , Dolo, A. , Tangara, M. , Coulibaly, N. , Coulibaly, K. and Koné, I. (2020) Kidney Damage during Sharp’s Syndrome: About Two Cases. Open Journal of Nephrology, 10, 290-297. doi: 10.4236/ojneph.2020.104029.