Flavonoids from the Leaves of Bridelia stipularis with in Vitro Antioxidant and Cytotoxicity Activity - Pharmacology & Pharmacy

PP > Vol.11 No.7, July 2020

Pharmacology & Pharmacy

Volume 11, Issue 7 (July 2020)

ISSN Print: 2157-9423 ISSN Online: 2157-9431

Google-based Impact Factor: 0.70 Citations h5-index & Ranking

Flavonoids from the Leaves of Bridelia stipularis with in Vitro Antioxidant and Cytotoxicity Activity ()

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DOI: 10.4236/pp.2020.117013 403 Downloads 1,386 Views Citations

Author(s)

Sangita Debnath Puja^1*, Kazi Ruhullah Shahriar², Choudhury Mahmood Hasan¹, Monira Ahsan¹

Affiliation(s)

¹Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh.
²Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.

ABSTRACT

Methanolic extract of the leaves of Bridelia stipularis was studied. From this study, we isolated three known flavonoids. They were identified as 7-O-methyl luteolin, apigenin and 5, 7, 2’, 5’ tetrahydroxyflavone by NMR spectroscopic studies. All of them are first time documented for this plant. Different solvent fractions were subjected to in vitro antioxidant and cytotoxicity studies. Both apigenin and ethyl acetate soluble fraction of Bridelia stipularis showed strong antioxidant activity having IC₅₀ value of 8.005, 8.77 μg/mL respectively. Chloroform soluble fraction of Bridelia stipularis exerted the highest toxicity to brine shrimp and petroleum ether soluble fraction showed moderate toxicity having LC₅₀ value of 1.05, 1.71 μg/mL respectively.

KEYWORDS

Bridelia stipularis, Flavonoid, Antioxidant, Cytotoxicity

Share and Cite:

Puja, S. , Shahriar, K. , Hasan, C. and Ahsan, M. (2020) Flavonoids from the Leaves of Bridelia stipularis with in Vitro Antioxidant and Cytotoxicity Activity. Pharmacology & Pharmacy, 11, 137-146. doi: 10.4236/pp.2020.117013.

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