Book Review: I-Cubed and The Autoimmune Brain, A Five-Step Plan - World Journal of Neuroscience

WJNS > Vol.10 No.1, February 2020

Book Review: I-Cubed and The Autoimmune Brain, A Five-Step Plan ()

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Download as PDF (Size: 246KB) PP. 29-36

DOI: 10.4236/wjns.2020.101005 432 Downloads 1,541 Views Citations

Author(s)

David S. Younger^1,2

Affiliation(s)

¹Department of Clinical Medicine, CUNY School of Medicine at City College, New York, USA.
²The Graduate School of Public Health and Health Policy, City University of New York, New York, USA.

ABSTRACT

The Autoimmune Brain¹ explains I-Cubed, a shorthand for post-infectious autoimmunity that results from the multiplier effect of infection, immunity and inflammation, when protective immunity becomes the source of autoimmunity, conditioned by applicable environmental and genetic predisposing factors. In keeping with the post-infectious autoimmune nature of I-Cubed, neurologic and psychiatric symptoms evolve beyond a standard of care course of antibiotic therapy. Extensive serologic, electrophysiological and neuroradiographic diagnostic testing provides clues to areas of central, peripheral and autonomic nervous system, and systemic involvement that guide therapy. A multimodality therapeutic approach employing immune modulatory (Ig) therapy that addresses the underlying mechanisms and not just the symptoms of Cubed disorders is most effective. Representative cases of post-infectious autoimmunity associated with Lyme disease and PANDAS are presented.

KEYWORDS

Neuropsychiatry, Lyme Disease, PANDAS, I-Cubed, Post-Infectious Autoimmunity

Share and Cite:

Younger, D. (2020) Book Review: I-Cubed and The Autoimmune Brain, A Five-Step Plan. World Journal of Neuroscience, 10, 29-36. doi: 10.4236/wjns.2020.101005.

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