Author(s)

Sindhura Suryanarayana^1,2, Jaimanti Bakshi^1*, Malay Sannigrahi³, Rajni Sharma³, Naresh K. Panda¹, Madhu Khullar^3*

¹Department of Otolaryngology & Head Neck Surgery, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
²Department of Otolaryngology & Head Neck Surgery, Sri Devaraj Urs Medical College, Kolar, India.
³Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Background: Polymorphisms of TAP1 gene might be pertinent in development of cancer by altering the immune response. We studied the association of TAP1 gene polymorphism with HPV related oropharyngeal cancer. Methods: This prospective study consisted of 200 subjects divided into three groups; Group A—HPV positive oropharyngeal cancer (17/100), Group B—HPV negative oropharyngeal cancer (83/100) and Group C—Controls. TAP1ile333val polymorphism genotyping was performed by ARMS-PCR. Results: No significant difference was observed in the distribution of Val/Val genotype of Group A in comparison to Group C (OR = 0.663, 95% CI = 0.164 - 2.688, p = 0.742) and Group B (OR = 1.725, 95% CI = 0.388 - 7.675, p = 0.677) and thus was not associated with HPV associated cancer. But the frequency of Val/Val genotype was found to be significantly decreased in Group B as compared to controls and was linked with increased risk of oropharyngeal cancers (OR = 0.38, 95% CI = 0.15 - 0.97, p = 0.048). Conclusion: TAP1i333v gene polymorphism was not associated with HPV positive oropharyngeal cancer; however decreased frequency of Val/Val genotype raises the risk of oropharyngeal cancer.

TAP1, HPV, Oropharyngeal Cancer, HNSCC, ARMS-PCR

Suryanarayana, S. , Bakshi, J. , Sannigrahi, M. , Sharma, R. , Panda, N. and Khullar, M. (2020) Association of TAP1 Gene Polymorphism in Human Papilloma Virus Related Oropharyngeal Cancer. Surgical Science, 11, 1-8. doi: 10.4236/ss.2020.111001.