In order to overcome some defects of the traditional immune algorithm, the immune algorithm was improved for solving a path optimization problem in deep immune learning of a gene network. Firstly, the diversity of the solution population was enhanced in the evolution process by improving the memory cell processing method. Moreover, effective gene information was dynamically extracted from the genes of the excellent antibodies to make good vaccines in the process of immune evolution. Worse antibodies were optimized by vaccinating these antibodies, and the convergence of the immune algorithm to the optimal solution was improved. Finally, the feasibility of the improved immune algorithm was verified in the experimental simulation for solving the classic NP problem in deep immune learning of the gene network.