Author(s)

Na-Na Li, Feng Shi, Xiao-Hui Niu, Jing-Bo Xia

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We developed a new approach for the reconstruction of phylogeny trees based on the chaos game representation (CGR) of biological sequences. The chaos game representation (CGR) method generates a picture from a biological sequence, which displays both local and global patterns. The quantitative index of the biological sequence is extracted from the picture. The Kullback-Leibler discrimination information is used as a diversity indicator to measure the dissimilarity of each pair of biological sequences. The new method is inspected by two data sets: the Eutherian orders using concatenated H-stranded amino acid sequences and the genome sequence of the SARS and coronavirus. The phylogeny trees constructed by the new method are consistent with the commonly accepted ones. These results are very promising and suggest more efforts for further developments.

CGR (Chaos Game Representation); Discrimination Information; Phylogeny Tree

Li, N. , Shi, F. , Niu, X. and Xia, J. (2009) A novel method to reconstruct phylogeny tree based on thechaos game representation. Journal of Biomedical Science and Engineering, 2, 582-586. doi: 10.4236/jbise.2009.28084.