Author(s)

Lusine Gasparyan^1,2, Ilya Mazo³, Vahan Simonyan¹, Ferdinand Gasparyan^2*

¹DNA-HIVE LLC 15313 Diamond Cove Terrace, Rockville, USA.
²Yerevan State University, Yerevan, Armenia.
³Argentis LLC, Gaithersburg, USA.

The results of comparative theoretical analyzes of the behavior of internal low-frequency noises, signal-to-noise ratio and sensitivity to DNA molecules for EIS and ISFET based nanosize biosensors are presented. It is shown that EIS biosensor is more sensitive to the presence of DNA molecules in aqueous solution than ISFET sensor. Internal electrical noises level decreases with the increase of concentration of DNA molecules in aqueous solution. In the frequency range 10⁻³ - 10³ Hz noises level for EIS sensor about in three orders is higher than for ISFET sensor. In the other hand, signal-to-noise ratio for capacitive EIS biosensor is much higher than for ISFET sensor.

Biosensor, Noise, Sensitivity, Signal-to-Noise Ratio

Gasparyan, L. , Mazo, I. , Simonyan, V. and Gasparyan, F. (2020) Noises and Signal-to-Noise Ratio of Nanosize EIS and ISFET Biosensors. Open Journal of Biophysics, 10, 1-12. doi: 10.4236/ojbiphy.2020.101001.