Author(s)

B. Togo^1*, P. Togo¹, O. Koné², F. Traore¹, A. K. Doumbia¹, A. Touré¹, A. A. Diakité¹, O. Coulibaly¹, H. Diall¹, B. Maïga¹, K. Sacko¹, A. Dembelé¹, Y. A. Coulibaly¹, D. Konaté¹, M. E. Cissé¹, A. A. Ba¹, F. L. Diakité¹, L. N. Sidibé¹, A. Doumbia¹, H. Konaré¹, L. B. Maïga¹, C. B. Traoré³

¹Department of Pediatrics, Gabriel Touré Teaching Hospital, Bamako, Mali.
²National Institute of Research in Public health, Bamako, Mali.
³Pathology Service of Point G Teaching Hospital, Bamako, Mali.

Background :Non-Hodgkin lymphomas are the first childhood cancer in sub-Saharan Africa. Objective: The purpose of this study was to assess non-Hodgkin lymphomas cases in our setting. Methodology: A retrospective and descriptive study carried out in the pediatric oncology unit of the Gabriel Touré Teaching Hospital Bamako over 10 years from 1st January 2005 to 31th December 2015. Results: We exploited 274 (21.6%) cases of Non-Hodgkin Lymphoma out of 1295 cancer cases registered, the age group 6 - 10 years was the most represented (46.4%); the male sex was predominant with a sex-ratio of 1.8; digestive signs were the most common signs of discovery (44.2%) followed by maxillary swelling (42.7%); the majority of patients (52.9%) consulted between 1 and 3 months after the onset of signs; the malnutrition rate was 39.8%, of which 24.1% were severe cases and 15.7% were moderate rate. Abdominal localization was the most common (43.1%) followed by maxillofacial localization (33.9%). Almost all were Burkitt type cytology (92.7%), the majority (73.4%) were in Murphy stage III. Almost all (96%) had received chemotherapy and the modified LMB 01 protocol was widely used (62.4%). The majority of patients (85%) were chemosensitive at day 7 or after the third cyclophosphamide injection but at the end of induction only 31% were in complete remission. Gastrointestinal toxicity was the most common (37.13%) followed by hematologic toxicity 35.09 %; 9.12 % of patients were lost of follow-up and 22.26% died. Tumor progression was the most common cause of death (60.66%) followed by infection (21.31%). Conclusion: In light of these findings, the late diagnosis and the poor management of NHL, as well as the limited ability to primarily treat metabolic complications, explain the high case-fatality rate, hence the important role of early diagnosis and treatment multidisciplinary.

Childhood Lymphomas, Gabriel TOURE Teaching Hospital, Mali

Togo, B. , Togo, P. , Koné, O. , Traore, F. , Doumbia, A. , Touré, A. , Diakité, A. , Coulibaly, O. , Diall, H. , Maïga, B. , Sacko, K. , Dembelé, A. , Coulibaly, Y. , Konaté, D. , Cissé, M. , Ba, A. , Diakité, F. , Sidibé, L. , Doumbia, A. , Konaré, H. , Maïga, L. and Traoré, C. (2019) Non Hodgkin Lymphomas (NHL) in the Pediatric Oncology Unit of the Gabriel Touré Teaching Hospital, Bamako Mali. Open Journal of Pediatrics, 9, 309-316. doi: 10.4236/ojped.2019.94030.