Author(s)

S. M. Shahriar Rizvi¹, Shirin Tarafder², S. M. Mostofa Kamal³, Shaheda Anwar⁴, Fatima Tuj Johora⁵, Shamim Hossain⁶

¹Communicable Disease Control, Directorate General of Health Services, Dhaka, Bangladesh.
²Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
³National Tuberculosis Reference Laboratory, NIDCH, Dhaka, Bangladesh.
⁴Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
⁵Department of Microbiology, East West Medical College, Dhaka, Bangladesh.
⁶Medical Technologist, National Tuberculosis Reference Laboratory, NIDCH, Dhaka, Bangladesh.

Host factors, environmental factors, genetic diversity and distinct phylogeographic distribution of Mycobacterium tuberculosis (MTB) contribute to regional differences in drug resistance. Bangladesh remains among the top 20 high Multi drug resistant tuberculosis (MDR-TB) burden countries of the world. This cross sectional study was conducted to identify the socio demographic characteristics and the risk factors contributing Pulmonary tuberculosis (PTB) infection. These characteristics and risk factors were further investigated among the clustered isolates. Total 60 culture isolates consist of 40 RR and 20 rifampicin sensitive (RS) isolates were enrolled in this study. Laboratory works were done in National Tuberculosis Reference Laboratory (NTRL) and Department of Microbiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. All 60 samples were confirmed as MTB by MPT 64 antigen detection. Two samples were excluded for possible cross contamination and two for failing to give PCR product for most of the locus. So, finally 56 samples were further analyzed for results. Four isolates were distributed within two clusters which were belonged to Beijing lineage. Socio demographic data and risk factors analysis of this study found significant male predominance (p = 0.04) with history of smoking (p = 0.01) and previous anti-TB treatment (p = 0.012) as the significant risk factors for RR TB.

Tuberculosis, Socio-Demographic, Beijing, Lineage, Epidemiology

Rizvi, S. , Tarafder, S. , Kamal, S. , Anwar, S. , Johora, F. and Hossain, S. (2019) Socio-Demographic Characteristics and Risk Factors Contributing Pulmonary Tuberculosis Infection and Recent Transmission. Journal of Tuberculosis Research, 7, 228-237. doi: 10.4236/jtr.2019.74022.