For the waterflooding of late development on an offshore oilfield has become worse, and some wells group has entered into high water cut-off period, water plugging work becomes particularly important. Due to the limited construction of offshore oilfield, space water supply difficulties, and stability of plugging agent, self-generating enhanced foam has been designed as the aimed block plugging system. The formula is determined as: 23.25% of NH₄Cl + 30% of NaNO₂ + 0.1% of catalyst + 0.6% of COSL-3 foaming agent + 0.25% of HS-type HPAM foam stabilizer. Measurement point of pipe with permeability of 0.5 μm² and 2 μm² has been used in the plugging and EOR experiments. The experiments show that this system has the selective plugging effect for the heterogeneous formation, especially for middle and posterior part of high permeability formation, and the recovery rate of low permeability pipe is enhanced up to 32.15%.