Author(s)

Koffi Konan Martin, Lassine Ouattara^*

Laboratoire de Chimie Physique, UFR SSMT, Université Félix Houphouët-Boigny de Cocody, Abidjan, Côte d’Ivoire.

An electroanalytical method was developed for the direct quantitative determination of paracetamol in tablets based on its oxidation behavior. The electrochemical oxidation and determination of paracetamol were easily carried out on born-doped diamond (BDD) electrode using two voltammetric techniques (CV and DPV). The electrochemical measurements performed by cyclic voltammetric (CV) and differential pulse voltammetry (DPV) techniques were carried out using a cathodically pretreated boron-doped diamond electrode in HClO₄ and KClO₄ electrolytes. HClO₄ was then selected for analytical purposes and scan rate studies were also completed. The oxidation of the paracetamol is found to be irreversible and a diffusion-controlled nature of the paracetamol oxidation peak was established. A linear calibration curve for DPV analysis was constructed in the paracetamol concentration range from 0 μM to 13.87 μM, with 0.16 μM and 0.55 μM as the detection and quantification limit respectively.

Electroanalytical Method, Boron-Doped Diamond Electrode, Voltammetry, Paracetamol

Martin, K. and Ouattara, L. (2019) Electroanalytical Investigation on Paracetamol on Boron-Doped Diamond Electrode by Voltammetry. American Journal of Analytical Chemistry, 10, 562-578. doi: 10.4236/ajac.2019.1011039.