Author(s)

Natalia V. Artymuk¹, Natalia A. Sukhova², Olga A. Tachkova², Moamar Al-Jefout^3,4,5,6*

¹GA Ushakova Department of Obstetrics and Gynecology, Kemerovo State Medical University, Kemerovo, Russia.
²Hospital Therapy and Clinical Pharmacology Department, Kemerovo State Medical University, Kemerovo, Russia.
³The Department of Obstetrics & Gynecology, College of Medicine and Health Sciences (CM & HS), United Arab Emirates University, Al-Ain, UAE.
⁴The Department of Obstetrics & Gynecology, Tawam Hospital, Al-Ain, UAE.
⁵The Department of Obstetrics & Gynecology, Faculty of Medicine, Mutah University, Karak, Jordan.
⁶The Department of Obstetrics and Gynecology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Purpose: To evaluate the effect of balanced hypocaloric diet therapy on the anthropometric and basic metabolic indicators in obese women with infertility. Methods: The follow up interventional clinical study included 23 infertile women in reproductive age with grade I gluteofemoral obesity. All patients have prescribed a balanced hypocaloric diet (1200 kcal/day), underwent exercise and behavioral therapy. Before and after 12-month treatment, an anthropometric study was conducted, determining the level of metabolic and hormonal indicators. Results: The total final number of study participants was 20 patients. A decrease in body weight was achieved in 87% of patients from 4 to 24 kg, on the average, by 10.58 ± 5.70 kg, there was also a decrease in BMI from 32.53 ± 1.40 to 28.55 ± 2.50 kg/m² (p < 0.001). The decrease in body weight was accompanied by a statistically significant decrease in leptin levels (p < 0.001), E₁ (p = 0.049), E₂ (p = 0.032), fasting glucose (p < 0.001), HOMA-IR (p = 0.002), cholesterol (p < 0.001), TG (p = 0.004), LDL-C (p = 0.001), atherogenic index of plasma (p <0.001) and an increase in progesterone levels (p = 0.030). Ovulatory menstrual cycles were resumed in all women (p = 0.007) and pregnancy occurred within a year in 1 patient. Conclusion: The implementation of a hypocaloric diet for 12 months in infertile women with first-degree obesity helps to normalize metabolic and hormonal indicators, reduces body weight and restores ovulatory menstrual cycle in all patients.

Obesity, Reproductive Age, Infertility, Diet Therapy, Anovulation

Artymuk, N. , Sukhova, N. , Tachkova, O. and Al-Jefout, M. (2019) The Effect of Balanced Hypocaloric Diet on the Anthropometric and Basic Metabolic Indicators in Infertile Women with Gluteofemoral Obesity. Open Journal of Obstetrics and Gynecology, 9, 1325-1335. doi: 10.4236/ojog.2019.910128.