Author(s)

Fernanda Cardia Martins Ribeiro¹, Larissa Alves Ruas¹, Aluysio Leal Júnior¹, Adriana Andrade de Sousa¹, Adriana Farias Araújo¹, Jonathan Mwambire², Ana Luísa Conceição de Jesus³, Renata Maksoud Bussuan¹, Larissa Bianca Cunha de Sá¹, Alberto Krayyem Arbex^1,4

¹IPEMED Medical School/AFYA Educational, Postgraduation in Endocrinology, Rio de Janeiro, Brazil.
²Internal Medicine, Malteser Krankenhaus Franziskus Hospital, Flensburg, Germany.
³Department of Pediatrics, University of São Paulo (USP) Medical School, São Paulo, Brazil.
⁴Medical Clinic in Endocrinology and Diabetology, Schleswig-Flensburg, Germany.

The aim of this study is to review and discuss the clinical features and treatment options for the Marine-Lenhart syndrome, an uncommon thyroid disturb. The methodology adopted was a bibliographic research. The results of this study show that different mechanisms are implicated in the pathogenesis of Graves’ disease and in the nodular formation of thyroid tissue with functional autonomy. Graves’ disease is caused by an autoimmune process that involves the entire thyroid gland and is characterized by the presence of TSH receptor stimulating antibodies. The present study concludes that caution should be exercised in interpreting thyroid disease in Graves’ disease. The treatment of thyrotoxicosis requires high doses of oral drugs. Relapsing antithyroid therapy occurs soon after oral antithyroid therapy is discontinued. This presentation should alert the physician about the existence of toxic nodules, and about the possibility of a Marine-Lenhart Syndrome.

Graves’ Disease, Marine-Lenhart Syndrome, Thyroid Gland, Thyroid Nodules

Ribeiro, F. , Ruas, L. , Júnior, A. , Sousa, A. , Araújo, A. , Mwambire, J. , Jesus, A. , Bussuan, R. , Sá, L. and Arbex, A. (2019) Graves’ Disease and Marine Lenhart Syndrome: A Rare Clinical Presentation. Health, 11, 1169-1176. doi: 10.4236/health.2019.119091.