Share This Article:

Restoring Efficacy to Cotrimoxazole, against Resistant Salmonella pullorum, with Medicinal Synthetic Aluminum-Magnesium Silicate ® [MSAMS: Al4 (SiO4)3 + 3Mg2SiO4 → 2Al2 Mg3 (SiO4)3]

Full-Text HTML XML Download Download as PDF (Size:325KB) PP. 1162-1168
DOI: 10.4236/health.2019.119090    104 Downloads   216 Views

ABSTRACT

To restore efficacy (≥95% infection-reduction) to drugs against resistant infections (now, posing a bigger medical challenge, globally, than even HIV/AIDS), Cotrimoxazole was formulated with a synthetic Aluminum-magnesium silicate (Medicinal mineral which molecules are made of Nanoparticles, that is already in use as pharmaceutical-stabilizing agent) and used with antioxidants to treat Cotrimoxazole-resistant Salmonella pulorum infected chicks. Chick-groups A, B and C were fed antioxidants-fortified feed while groups D, E, F, G and H were not. The treatment-groups and their Cotrimoxazole doses/formulations were: A and D (100%/MSAMS-Cotrimoxazole); B and E (75%/MSAMS-Cotrimoxazole); C and F (50%/MSAMS-Cotrimoxazole) and G (100%/Cotrimoxazole). Infection-reductions (96.23% and 94.98%) of the groups of 75%/MSAMS-Cotrimoxazole/antioxidants and 75%/MSAMS-Cotrimoxazole were significantly (P ≤ 0.05) better than 76.99% (100%/Cotrimoxazole); 10.04% (50%/MSAMS-Cotrimoxazole/antioxidants); 1.60% (50%/MSAMS-Cotrimoxazole); 212.60% (100%/MSAMS-Cotrimoxazole/antioxidants) and 230.96% (100%/MSAMS-Cotrimoxazole).

Cite this paper

Ezeibe, M. , Udom, A. , Onyeachonam, O. and Ogbonna, I. (2019) Restoring Efficacy to Cotrimoxazole, against Resistant Salmonella pullorum, with Medicinal Synthetic Aluminum-Magnesium Silicate ® [MSAMS: Al4 (SiO4)3 + 3Mg2SiO4 → 2Al2 Mg3 (SiO4)3]. Health, 11, 1162-1168. doi: 10.4236/health.2019.119090.

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.