Schistosoma mansoni Infection in Holochilus sciureus Shows Sex-Related Differences in Parasitological Patterns - Open Journal of Animal Sciences

OJAS > Vol.9 No.2, April 2019

Schistosoma mansoni Infection in Holochilus sciureus Shows Sex-Related Differences in Parasitological Patterns ()

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DOI: 10.4236/ojas.2019.92015 928 Downloads 2,600 Views Citations

Author(s)

Guilherme Silva Miranda^1,2*, João Gustavo Mendes Rodrigues³, Maria Gabriela Sampaio Lira⁴, Ranielly Araújo Nogueira⁴, Gleycka Cristine Carvalho Gomes⁴, Nêuton Silva-Souza⁴

Affiliation(s)

¹Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
²Teaching Department, Federal Institute of Maranhao, Sao Raimundo das Mangabeiras, Brazil.
³Department of Pathology, Centre for Biological and Health Sciences, Federal University of Maranhao, Sao Luís, Brazil.
⁴Department of Chemistry and Biology, Laboratory of Human Parasitology, State University of Maranhao, Sao Luís, Brazil.

ABSTRACT

Due to the different parasitological patterns found between sexes in human populations and in different biological models during Schistosoma mansoni infection, we proposed to investigate such differences using Holochilus sciureus rodent, besides confirming whether this rodent is suitable for experimental infections. In this sense, males and females of H. sciureus were infected with 200 cercariae from a human strain of S. mansoni. The number of eggs per gram of feces (epg) and the worms were quantified, besides histopathological analysis. Thus, it was shown that females have fewer epg, as well as a longer prepatent period. On the other hand, males had a lower recovery rate of adult worms. The histopathological analysis did not show differences between the sexes. Thus, we suggest that infection in H. sciureus females provides a favorable environment for the development of adult worms, despite impairing the parasite fecundity. In addition, H. sciureus may be an excellent biological model for S. mansoni experimental infections.

KEYWORDS

Biological Model, Females, Males, Schistosomiasis, Wild Reservoir

Share and Cite:

Miranda, G. , Rodrigues, J. , Lira, M. , Nogueira, R. , Gomes, G. and Silva-Souza, N. (2019) Schistosoma mansoni Infection in Holochilus sciureus Shows Sex-Related Differences in Parasitological Patterns. Open Journal of Animal Sciences, 9, 173-182. doi: 10.4236/ojas.2019.92015.

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