Author(s)

Lingxiao Ye, Xiaoming Sun, Yuguang Zhang^*, Ying Zhang^*

Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China.

Wound healing requires abundant nutrition and blood supply, thus angiogenesis is a vital stage in this process. Angiogenesis involves diverse kinds of immune cells, growth factors, cytokines and inhibitors. ADSCs, especially ADSCs cultured in hypoxic condition, are reported to be able to facilitate angiogenesis and promote wound healing process. Significant efforts have been made on the development of ADSCs-based therapies with wound-healing applications. Here the results showed that expression of Angiopoietin-2 (ANGPT2) in ADSCs was up-regulated in the hypoxic condition.

ADSCs, ANGPT2, Angiogenesis, Wound Healing

Ye, L. , Sun, X. , Zhang, Y. and Zhang, Y. (2019) Hypoxic Condition Up-Regulates the Expression of Angiopoietin-2 in ADSCs. Journal of Biomedical Science and Engineering, 12, 77-84. doi: 10.4236/jbise.2019.122006.