Author(s)

Cong Zhang^1,2, Xiaofang Xiong^1,2, Shihong Deng², Fang Wang^1,2*

¹Department of Cardio-Thoracic and Breast Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, China.
²Team of Intravenous Therapy, The First Affiliated Hospital of Yangtze University, Jingzhou, China.

Objective: To study the clinical effect of aspirin in the prevention of venous thrombosis in breast cancer patients with postoperative chemotherapy after peripherally inserted central catheter (PICC) insertion. Methods: 240 cases of female breast cancer patients with postoperative chemotherapy after PICC insertion in The First People’s Hospital of Jingzhou from June 2014 to December 2017 were selected and divided into experimental group (n = 120) and control group (n = 120) according to the length of stay. The modified Seldinger technique was used in both groups. The experimental group had oral Aspirin enteric-coated tablet on the day of PICC insertion, 100 mg/day until the PICC catheter was removed, while the control group did not take anticoagulant drugs. The therapeutic effects were evaluated by color Doppler ultrasound, Coagulation analysis, and complete blood count. Results: There were three cases with venous thrombosis in the experimental group, and the incidence rate was 2.5%, while ten cases in the control group developed venous thrombosis, and the incidence rate was 10%. There was a statistically significant difference in the incidence of thrombosis between the two groups (P < 0.05). Conclusion: This study showed that oral Aspirin can effectively reduce the incidence rate of venous thrombosis in breast cancer patients with postoperative chemotherapy after PICC insertion. Therefore, it is worthy of clinical application.

Aspirin, Breast Cancer, Peripherally Inserted Central Catheter, Venous Thrombosis

Zhang, C. , Xiong, X. , Deng, S. and Wang, F. (2018) Clinical Study of Aspirin in the Prevention of Thrombosis in Breast Cancer Patients with Postoperative Chemotherapy after PICC Insertion. Yangtze Medicine, 2, 255-261. doi: 10.4236/ym.2018.24027.