Author(s)

Sri Vidawati, Silvia Barbosa, Pablo Taboada, Eva Villar, Antonio Topete, Victor Mosquera

Grupo de F'lsica de Coloides y Pol'lmeros, Departamento de F'lsica de la Materia Condensada, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.

The Biodegradable nanoparticles from poly(lactic-co-glycolic acid) (PLGA) have been extensively investigated for sustained and targeted/localized delivery of different agents. Many parameters are required in the synthesis of a biodegradable polymeric nanoparticle. We report the synthesis of human serum albumin (HSA)-superparamagnetic iron oxide nanoparticles (SPIONs) loaded PLGA nanoparticles. All nanoparticles were characterized using a TEM image, UV-Vis spectroscopy measurements, Zeta Potential, and PPMS for magnetizations. This study described and investigated the interesting phenomenon in the synthesis development of HSA-SPIONs loaded PLGA nanoparticles. The result showed that the stability of HSA-SPIONs loaded PLGA nanoparticles for potential applications such as in protein delivery.

Nanoparticles, PLGA, SPIONs, HSA

Vidawati, S. , Barbosa, S. , Taboada, P. , Villar, E. , Topete, A. and Mosquera, V. (2018) Study of Human Serum Albumin-SPIONs Loaded PLGA Nanoparticles for Protein Delivery. Advances in Biological Chemistry, 8, 91-100. doi: 10.4236/abc.2018.85008.