Author(s)

Parag Biniwale¹, Bhaskar Pal², Tripura Sundari³, Gorakh Mandrupkar⁴, Nikhil Datar⁵, Amandeep Singh Khurana⁶, Amit Qamra⁶, Salman Motlekar^6*, Rishi Jain⁶

¹Department of Obstetrics & Gynecology, Biniwale Clinic, Pune, India.
²Department of Obstetrics & Gynecology, Apollo Gleneagles Hospital Ltd., Kolkata, India.
³Department of Obstetrics & Gynecology, Krishna Institute of Medical Sciences, Secunderabad, India.
⁴Department of Obstetrics & Gynecology, Mandrupkar Clinic, Islampur, India.
⁵Department of Obstetrics & Gynecology, Cloudnine Hospital, Mumbai, India.
⁶Department of Medical Affairs, Wockhardt Limited, Mumbai, India.

Iron deficiency anemia is the most frequent nutritional deficiency disorder. Conventionally administered oral iron is associated with gastrointestinal intolerance that affects the outcomes and compliance. Liposomal iron is associated with increased absorption without causing significant adverse effects. In this review, we have discussed the technology of liposomal iron preparation, mechanisms of its absorption and clinical evidence on its utility in iron deficiency states in pregnant and non-pregnant women. Based on the available evidence, we compared liposomal iron to conventional oral iron. Encapsulation of micronized iron in liposomes is associated with lesser exposure to gastric contents, lesser interaction with food contents, no exposure to different digestive juices, targeted delivery of iron and allows lower doses to be administered in lieu of direct absorption without need for protein carriers. The available evidence suggests that liposomal iron significantly increases hemoglobin, ferritin levels in pregnant women as well as in women with iron deficiency.

Liposomal Iron, Microencapsulated, Micronized, Iron Deficiency, Anemia, Pregnancy

Biniwale, P. , Pal, B. , Sundari, T. , Mandrupkar, G. , Datar, N. , Khurana, A. , Qamra, A. , Motlekar, S. and Jain, R. (2018) Liposomal Iron for Iron Deficiency Anemia in Women of Reproductive Age: Review of Current Evidence. Open Journal of Obstetrics and Gynecology, 8, 993-1005. doi: 10.4236/ojog.2018.811100.