Author(s)

Hui Lin, Wen He, Jie Lv, Chanlin Han, Li Sun, Jianping Ou, Liuhong Cai^*

Center for Reproductive Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Here we reported a rare case of misdiagnosed ectopic pregnancy (EP) due to unintended ovulation during controlled ovarian stimulation (COS) in GnRH agonist cycle, resulting in no oocytes harvested and late hyper-stimulation syndrome (OHSS). The patient was a 33-year old primary infertile woman due to male’s factors and underwent her second in vitro fertilization (IVF) cycle using GnRH agonist protocol, and no oocytes harvested on ovum picked-up (OPU) day. The start of gonadotropin usage was on day 8^th of her period, and the P level increased rapidly and strangely high from day 8^th after gonadotropin usage. The E2 level and follicles grew normally but finally no oocytes harvested. She was diagnosed as late ovarian hyper-stimulation syndrome (OHSS) 7 days after OPU. 20 days after OPU, no menstruation come and a positive urine test of hCG were reported. And the patient was diagnosed as EP by laparoscopy. In conclusion, rapidly increased P level, no oocyte retrieval and late onset of OHSS should be very important clues to diagnose this misdiagnosed EP.

In-Vitro Fertilization, Ectopic Pregnancy, Controlled Ovarian Stimulation, Gonadotropin-Releasing Hormone Agonist

Lin, H. , He, W. , Lv, J. , Han, C. , Sun, L. , Ou, J. and Cai, L. (2018) Case Report of Ectopic Pregnancy during Controlled Ovarian Stimulation without Oocytes Harvested and Late Ovarian Hyperstimulation Syndrome. Advances in Reproductive Sciences, 6, 102-108. doi: 10.4236/arsci.2018.63008.