The Rehabilitated Mudor sewage treatment plant at James Town was monitored over a period of 4 months (October 2017 to January 2018). This study analyzed the physical, chemical and biological parameters of the raw sewage and the treated effluent from the plant. The result indicates that the total removal efficiencies were 98.8%, 91.2%, 62.8%, 28.6%, 81.7%, 43.6%, 82.5% and 99.6% for BOD, COD, TSS, Nitrate-Nitrogen, Phosphate-Phosphorus, Ammonia-nitrogen, Sulphate and faecal coliform respectively. More than 13 parameters needed to be met according to the Ghana Environmental Protection Agency (EPA) guideline were satisfactorily met whiles ammonia, total suspended solids and phosphate were slightly out of range. From the results obtained, the overall performance of the rehabilitated plant was satisfactory and has seen some improvement with respect to the former recorded performance of the plant. With monitoring operation parameters for waste water plants discharge guidelines becoming stringent over the past years, it could be said that management of the Mudor rehabilitated treatment plant is on the right cause with full scale operation of the plant barely less than a year. Increase in the process steps through rehabilitation resulted in several significant improvements in effluent quality parameters.