The Relationship between Serum Pentraxin-3 Levels and Severity of Coronary Heart Disease - World Journal of Cardiovascular Diseases

WJCD > Vol.8 No.7, July 2018

The Relationship between Serum Pentraxin-3 Levels and Severity of Coronary Heart Disease ()

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Download as PDF (Size: 586KB) PP. 370-380

DOI: 10.4236/wjcd.2018.87036 1,357 Downloads 3,460 Views Citations

Author(s)

Mohamed Yahia^1*, Omar S. Elmasry², Mai Abdel Ra’ouf^1,3

Affiliation(s)

¹Department of Cardiology, College of Medicine, University of Menoufia, Shebin-Alkoum, Egypt.
²Department of Applied Medical Chemistry, Medical Research Institute, University of Alexandria, Alexandria, Egypt.
³Department of Cardiology, Ram Medical Complex, Dammam, KSA.

ABSTRACT

Background: Clinical data suggested that pentraxin-3 is a biomarker for atherosclerosis due to its role in inflammatory processes since it exerts unfavorable effects on the course of atherosclerosis, stimulates plaque formation, and augments vascular inflammation. Objective: The aims of this study were to measure the level of serum pentraxin-3 in patients with suspected coronary artery disease (CAD) and to determine whether it was associated with the severity of CAD. Material and Methods: The serum pentraxin-3 level was measured by enzyme-linked immunosorbent assay in 80 patients who were referred for elective coronary angiography due to positive stress test results. SYNTAX score was used to determine the severity of CAD. Results: The study cohort consisted of 45 (56.25%) males and 35 (43.75%) females with a mean age of 55 ± 9.8 years. The mean serum pentraxin-3 level was 3.79 ± 1.38 ng/ml, and the mean SYNTAX score was 15.8 ± 11.3. A significant correlation was observed between pentraxin-3 level and SYNTAX score (r = 0.459, p < 0.001). The level of pentraxin-3 was significantly higher in patients with SYNTAX scores of ≥33 compared with patients who scored 23 - 32 or ≤22 (p = 0.002). Conclusion: The serum level of inflammatory marker pentraxin-3 is increased in patients with CAD and is correlated with the severity of CAD.

KEYWORDS

Coronary Artery Disease, Pentraxin-3, SYNTAX Score

Share and Cite:

Yahia, M. , Elmasry, O. and Ra’ouf, M. (2018) The Relationship between Serum Pentraxin-3 Levels and Severity of Coronary Heart Disease. World Journal of Cardiovascular Diseases, 8, 370-380. doi: 10.4236/wjcd.2018.87036.

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