Predictive Value of Neutrophil-to-Lymphocyte Ratio in Outcomes of Patients with Acute Coronary Syndrome - World Journal of Cardiovascular Diseases

WJCD > Vol.8 No.5, May 2018

Predictive Value of Neutrophil-to-Lymphocyte Ratio in Outcomes of Patients with Acute Coronary Syndrome ()

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DOI: 10.4236/wjcd.2018.85026 1,399 Downloads 3,072 Views Citations

Author(s)

Wassam Eldin Hadad El Shafey^1*, Ahmed Mohamed Emara¹, Walaa Farid Mosa¹, Khaled Hussein El-Sharnouby²

Affiliation(s)

¹Department of Cardiology, Menoufia University Hospitals, Menoufia, Egypt.
²Department of Cardiology, Shibin El Kom Teaching Hospital, Menoufia, Egypt.

ABSTRACT

Objectives: Previous studies have demonstrated the role of inflammation in acute coronary syndrome (ACS). The neutrophil-to-lymphocyte ratio (NLR) was found to be a useful inflammatory marker for predicting adverse outcomes. We hypothesized that an elevated neutrophil-to-lymphocyte ratio would be associated with increased mortality in patients with acute coronary syndrome. Methods: The study consisted of 40 patients with acute coronary syndrome who were admitted to Cardiology Department—Menoufia University Hospitals. The primary endpoint was all-cause in-hospital as well as 30-day mortality, and the patients were divided into three tertiles according to their admission NLR results. Results: All-cause 30-day mortality in the three groups based on NLR was 0.0%, 7.7% and 28.6%, in the low-, middle- and high-NLR groups, respectively (P < 0.05; χ² test). In a logistic regression analysis, including baseline demographic, clinical, and biochemical covariates, the neutrophil-to-lymphocyte ratio was an independent predictor of mortality (OR = 2.44, 95% CI = 1.185 - 5.007, P < 0.05). Conclusion: An elevated neutrophil-to-lymphocyte ratio (NLR), a simple, relatively inexpensive and universally available inflammatory marker, seems to be a predictor of 30-day mortality in patients with acute coronary syndrome.

KEYWORDS

Acute Coronary Syndrome, Inflammation, Ischemia, Neutrophil-to-Lymphocyte Ratio, Mortality

Share and Cite:

El Shafey, W. , Emara, A. , Mosa, W. and El-Sharnouby, K. (2018) Predictive Value of Neutrophil-to-Lymphocyte Ratio in Outcomes of Patients with Acute Coronary Syndrome. World Journal of Cardiovascular Diseases, 8, 265-275. doi: 10.4236/wjcd.2018.85026.

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