Share This Article:

Bacteriostatic Effects of Hyaluronan-Based Bioresorbable Membrane

Full-Text HTML Download Download as PDF (Size:288KB) PP. 431-436
DOI: 10.4236/ss.2011.29094    3,564 Downloads   6,149 Views Citations

ABSTRACT

Purpose: The purpose of this study is to determine the presence of bacteriostatic effects of hyaluronan-based bioresorbable membrane (HA/CMC) on selected major bacterial strains in digestive organs. Methods: We firstly evaluated the growth inhibition effect of HA/CMC for E. coli and S. aureus by determining the optical density (OD)650 in the incubation medium. At second, to determine the viable counts of bacteria, total adenosine triphosphate (ATP) were measured with five groups; several concentrations of HA/CMC and control. Results: OD curve gradually elevated and reached to plateau at 4 hours in E. coli. and 6 hours in S. aureus. After reaching plateau, the growth inhibition of both strains was statistically significantly correlated to the concentrations of HA/CMC. The ATP productions had statistically significant differences at 6 hours after incubation and inhibited in dose-dependence of a well-dissolved HA/CMC. Conclusion: HA/CMC may have dose-dependently bacteriostatic effects on S. aureus and E. coli.

Cite this paper

K. Uchida, K. Otake, M. Inoue, Y. Koike, K. Matsushita, K. Tanaka, Y. Inoue, Y. Mohri and M. Kusunoki, "Bacteriostatic Effects of Hyaluronan-Based Bioresorbable Membrane," Surgical Science, Vol. 2 No. 9, 2011, pp. 431-436. doi: 10.4236/ss.2011.29094.

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.