Prognostic Factors and Treatment Outcome in 178 Locally Advanced Cervical Cancer Patients - Open Journal of Obstetrics and Gynecology

OJOG > Vol.8 No.5, May 2018

Prognostic Factors and Treatment Outcome in 178 Locally Advanced Cervical Cancer Patients ()

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DOI: 10.4236/ojog.2018.85055 1,120 Downloads 2,591 Views

Author(s)

Ozlem Yetmen Dogan^1*, Makbule Dogan Eren¹, Sedef Ozdemir Dag², Alparsalan Mayadağli³

Affiliation(s)

¹Radiation Oncology Department, Kartal Dr Lutfi Kirdar Training and Research Hospital, Saglik Bilimleri University, Istanbul, Turkey.
²Radiation Oncology Department, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.
³Radiation Oncology Department, Bezmialem Vakif University, Istanbul, Turkey.

ABSTRACT

Background: To evaluate local control, survival, radiation side effects and treatment outcome in locally advanced cervical cancer patients. Materials and Methods: Among 2006-2011, 178 patients with locally advanced cervical cancer were treated with chemoradiotherapy +/- radiotherapy and high dose rate (HDR) brachytherapy. Follow-up was complete for all patients. Concomitant chemotherapy was not administered in 44 patients due to renal impairments and ECOG of 2 - 3. Results: The median follow-up period was 34.5 months (range, 5 to 93) and 42 months (range, 14 to 93 months) for alive patients. Five years local-regional control, progression-free survival and overall survival rates were 87.8%, 58.9% and 67.3% in all patients, respectively. In this retrospective study young age, tumor diameter, stage, presence of residual tumor and administration of chemotherapy were effected in survival analysis. The parameters which affected the complete response of patients were defined as presence of concomitant chemotherapy and number of courses <5. Central region recurrence rate was defined higher in the group with treatment duration of 9 weeks and higher (p = 0.044). Conclusion: Primary chemoradiotherapy +/- radiotherapy achieved a satisfactory rate of local control and survival rates with acceptable complications in locally advanced cervical cancer. Concomitant chemotherapy and treatment duration were the important prognostic factors for completed response locally advanced cervical cancers.

KEYWORDS

Locally Advanced Cervix Cancer, Chemo-Radiotherapy, Cervix Cancer

Share and Cite:

Yetmen Dogan, O. , Dogan Eren, M. , Ozdemir Dag, S. and Mayadağli, A. (2018) Prognostic Factors and Treatment Outcome in 178 Locally Advanced Cervical Cancer Patients. Open Journal of Obstetrics and Gynecology, 8, 485-496. doi: 10.4236/ojog.2018.85055.

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