This paper adopted the 30 provinces in 2006-2016 (except Tibet and Hong Kong, Macao and Taiwan) of R&D input, honesty and economic variable data, set up a panel data model, studied the honesty degree of influence R&D input, then used the level panel data from 2006 to 2017 in Guangdong province, to strengthen the honesty degree of the empirical test results of R&D input. The results show that the higher the level of honesty, the more investment in R&D will be brought in, and the country’s technological strength as well as core competitiveness will be stronger. On the contrary, the lower level of honesty leads to lower R&D investment; second, the degree of honesty has a significant positive impact on R&D investment in the eastern region, while in the central and western regions the degree of honesty have no significant impact on R&D investment; finally, the honesty of Guangdong prefecture-level cities has a significant positive effect on R&D investment.