Chemotherapy-Induced Tumour Lysis Syndrome in Gastric Adenocarcinoma with Diffuse Liver Metastases: A Case Report - Journal of Cancer Therapy

JCT > Vol.9 No.1, January 2018

Chemotherapy-Induced Tumour Lysis Syndrome in Gastric Adenocarcinoma with Diffuse Liver Metastases: A Case Report ()

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DOI: 10.4236/jct.2018.91003 1,044 Downloads 2,179 Views Citations

Author(s)

Nurhan Onal Kalkan¹, Ayşe Oter Almalı², Azer Gokmen¹, Erkan Dogan^3*

Affiliation(s)

¹Department of Medical Oncology, Medical Faculty, Van Yuzuncu Yil University, Van, Turkey.
²Department of Pathology, Medical Faculty, Van Yuzuncu Yil University, Van, Turkey.
³Department of Medical Oncology, Medical Faculty, Istanbul Yeni Yuzyil University, Istanbul, Turkey.

ABSTRACT

Tumour Lysis Syndrome (TLS) is an important oncological emergency case which is often found together with haematological malignities and, much less often, with solid tumours. While TLS seen in solid tumour cases usually develops following a cytotoxic chemotherapy and its prognosis is poor. We present the case of a 60-year-old man with gastric adenocarcinoma with diffuse liver metastases (image shows diffuse liver metastatic lesions) and high serum LDH levels, who developed TLS after systemic chemotherapy. With urgent and proper supportive treatment (intravenous intensive hydration, sodium bicarbonate, diuretic, calcium gluconate, allopurinol and haemodialysis), an impressive recovery from TLS was achieved in the patient with an advanced stage gastric cancer. The purpose of this report is to emphasize that although the present case was a rare, high physician attention is required because significant morbidity or mortality may occur when the syndrome is not duly considered during the pre-cytotoxic evaluation of the patient, when preventive measures are not taken, or if the appropriate treatment is not applied immediately once the syndrome appears, especially in patients who have high tumour burden solid cancer.

KEYWORDS

Tumour Lysis Syndrome, Gastric Cancer, Chemotherapy, Solid Tumour

Share and Cite:

Kalkan, N. , Almalı, A. , Gokmen, A. and Dogan, E. (2018) Chemotherapy-Induced Tumour Lysis Syndrome in Gastric Adenocarcinoma with Diffuse Liver Metastases: A Case Report. Journal of Cancer Therapy, 9, 16-22. doi: 10.4236/jct.2018.91003.

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