The major seismicity source in the northern Arabian Sea is the Makran Subduction Zone (MSZ) that defines the tectonic boundary between the Arabian plate and the Eurasian plate, located offshore Iran and Pakistan over which an instrumentally registered earthquake (M_w 8.1) generated a tsunami on 27 November, 1945. It has caused severe cataclysm to a vulnerable population along the surrounding coastlines, including India. It has been on a long seismic quiescence since this last event. The population and industrialization have exponentially increased along the coastal areas in last half decade. The highly exposed coastal locations to the tsunamis are the areas where the nuclear power plants are located. In the present work, a numerical simulation of a great tsunamigenic earthquake (M 9) is presented that predicts the generation, propagation, run-up and travel time using TUNAMI N2 for estimating tsunami impacts along the nuclear power plants of the western coast of India. TUNAMI N2 code was designed for shallow water wave equations, which uses the finite-difference method based on staggered-leap frog scheme. Thus, it has potential to simulate a far-field tsunami with much more accuracy than other methods. It is observed that the tsunami will strike along the coast of Jaitapur Nuclear Power Plant (Maharashtra), Tarapur Nuclear Power Plant (Maharashtra), Kaiga Nuclear Power Plant (Karnataka) and Mithi-Virdi Nuclear Power Plant (Gujarat) after 210, 215, 225 and 230 minutes, respectively. Results show that the tsunami run-up is highest for Jaitapur coast (2.32 m). The Mithi-Virdi coast is the least effected (0.93 m) while Kaiga (2.15 m) and Tarapur coast (2.12 m) might have faced quite intense tsunami consequences. The arrival times and run-ups of the tsunami along the coast of different power plants have been calculated since these parameters are of vital importance in mitigation of the coastal hazard, evacuation planning and installation of early warning system in order to save the inhabited communities from the disaster.