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Clinical Predictors for Recurrence after Curative Resection for Colorectal Cancer

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DOI: 10.4236/jct.2017.812095    457 Downloads   1,049 Views

ABSTRACT

Purpose: To identify clinical predictors of recurrence of colorectal cancer after curative surgical treatment. Methods: Retrospective follow-up-study of 925 consecutive patients treated with R0-resection for colorectal cancer Stage I, II and III from 1990 until 2000 with a mean follow-up of 60 ± 37 months. Predictors for cancer recurrence were identified in a pilot-sample of these patients, followed by analyses of the rest of the patients (test-sample), and finally with a concluding analyses of the entire patient group. Data were analyzed with Pearson Chi-square test (χ2), Cox regression analyses and log rank test. Results: Tumor stage (Stage I: HR 0.10 (0.05; 0.19), Stage II: HR 0.31 (0.24; 0.41)) and postoperative reoperations due to complications due to other causes than anastomotic leakage (HR 2.02 (1.21; 3.36)) were significant predictors of cancer recurrence in the multivariate Cox regression model. The association between reoperations and recurrence was strongest for the patients with the best prognosis: Stage I and Stage II-cancers. Long duration of surgery, strongly associated with blood-loss and infusions of liquid and blood-products, reoperation due to anastomotic leakage as well as right colon/transversum localization were significant at a trend-level (10%). Conclusions: Tumor stage and reoperations due to postoperative complications other than anastomotic leakage are significant predictors for recurrence after curative surgery for colorectal cancer.

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Røkke, O. , Heggelund, T. , Benth, J. , Røkke, M. and Øvrebø, K. (2017) Clinical Predictors for Recurrence after Curative Resection for Colorectal Cancer. Journal of Cancer Therapy, 8, 1107-1124. doi: 10.4236/jct.2017.812095.

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