Background: The BS-Nursing in the Philippines has an intensive curriculum at par with international standards to cater the learning needs of the students to make them globally competitive suitable for the demands of health care jobs abroad. Objective: This study is intended to highlight an innovative student-centered teaching strategy termed as Student-Centered Conceptual Teaching Approach (SCCTA) believed to enhance the retention and critical thinking skills of nursing students compared to traditional teaching approach. Method: A Quantitative Methodology specifically Comparison Group Pre-test/ Post-test design was employed and both quantitative and qualitative data were gathered. These were analyzed using mean, standard deviation, and t test. Third year BS-Nursing students served as the participants of the study. Results: Findings show that the pretest score profile of the participants in the control and experimental group obtained a p value of less than 0.001 α = 0.05; thus, indicating that their learning skills are below average. Furthermore, the posttest score profile of the participants in the control group obtained a p value of less than 0.001 at α = 0.05 indicating that their skills are still below average. The post-test score profile of the participants in the experimental, conversely, obtained p values of less than 0.001, and 0.11935, respectively at α = 0.05, suggesting that the participants made significant improvements in their learning skills. Whereas, the mean gains of both groups obtained p values of less than 0.001 at α = 0.05. This means that the participants had considerable learning in the above mentioned skills. However, there is a significant difference in the mean gains between the two groups due to the fact that the p values in all aforementioned skills are less than 0.001 at α = 0.05. Conclusion: The significantly different responses between the groups show clearly that the participants of the experimental group learned better with the use SCCTA.