ABSTRACT
Objective: The association between type 2 diabetes mellitus and certain endocrine
disorders has the paucity of information and limited data in the province of
Meisan (southern of Iraq). Hence, in the present study, an attempt was made to
investigate the levels of plasma HbA1c, serum insulin resistance and levels of
serum sex hormones in men and women of control and type 2 diabetic patients. Also,
the present study aimed to explored the correlation coefficient (r) between
insulin resistance and level of HbA1c, FSH, LH, Tt, progesterone and estradiol
in men and women patients with NIDDM. Methods: One hundred Iraqi
volunteers with abdominal obesity were selected in the present study. Fifty
diabetic patients with NIDDM (26 men, and 24 women) aged between (37) and (65)
years and 50 healthy individuals (25 men, and 25 women) aged between (36) and
(65) years considered as control group. Complete medical history was taken from
each subject and complete clinical examinations were performed for all
volunteers. Then, the two groups were matched for their fasting blood sugar,
BMI, insulin hormone; c-peptide, HbA1c, sex hormones and insulin resistance
parameters (HOMA2-IR, HOMA%B and HOMA%S) were calculated using HOMA2 calculator
software. Results: We found that insulin resistance demonstrated
negative correlations (p < 0.05) with levels of serum follicle stimulating hormone (FSH), luteinizing
hormone (LH), total testosterone, progesterone and estradiol. While, there was
a positive and significant correlation (p < 0.01) with value of HbA1c in men and women NIDDM
patients. Conclusion: We conclude that an increase in the level
of insulin resistance is associated with increased level of blood HbA1c
and decreased in level of serum sex hormones (FSH, LH, Tt, E2 and progesterone)
in men and women of diabetic group. These behaviors might suggest that insulin
resistance can be used as a potential biomarker for predicting dysfunction of
sex hygiene in NIDDM patients in addition to glycemic control.