North Cameroon, though located in an arid environment, ironically also suffers from the serious threat of flooding in the region. This article examines contemporary challenges resulting from frequent flooding in North Cameroon. Using Cutter’s “Hazard of Place Model” of vulnerability as the conceptual basis, the article triangulates data from a variety of sources to analyze environmental risks, social and biophysical vulnerability and flood impact, including flood risk management in North Cameroon. The findings reveal that North Cameroon is vulnerable to frequent flooding due to a combination of environmental, socio-economic, and geographic factors further compounded by low organizational resilience to flooding with dire consequences for livelihoods. We argue that, if not handled appropriately, the impact of flooding in North Cameroon risks trapping the population in a permanent and vicious cycle of destitution and poverty. The government urgently needs to review its disaster management policies to be more proactive and strategic in flood management in order to enhance human security and prevent permanent damage to the livelihoods and the micro-economy of the region. Lessons learned from this research, when applied, can help to reduce the vulnerabilities of the poverty-stricken population and enhance resilience to flood risks.