Author(s)

Carol Courderot-Masuyer^1*, Sophie Robin¹, Ferial Fanian², Philippe Humbert²

¹Bioexigence SAS, Espace Lafayette, Besançon, France.
²Research and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC INSERM 1431), Besançon University Hospital; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.

Stretch marks are cutaneous lesions occurring frequently in weight gain during puberty and early adult life. Previous studies showed that highest contractile forces were developed by fibroblasts from early stretch marks (SMF) compared to those developed by fibroblasts from normal healthy skin (HF) of the same patient. The aim of the present study was to evaluate a possible preventive effect of a topical preparation (containing vitamins C and E and botanical extracts including natural extract of Calendula, Aloe Vera and Evening Primrose Oil) on the formation of stretch marks using Glasbox^Plus® device. In the presence of the tested mixture, a significant overall decrease in contractile forces of SMF was noted for 24 hours of measurements compared to control SMF and made it possible to restore their capacity to the same level as HF indicating a possible preventive effect of the tested mixture. The synergistic effects of these components are certainly responsible for the decrease in contractile forces of early stretch marks fibroblasts.

Stretch Marks, Fibroblasts, Mechanical Forces, Preventive Effect

Courderot-Masuyer, C. , Robin, S. , Fanian, F. and Humbert, P. (2017) Evaluation of a Preventive Effect of a Lotion on the Formation of Stretch Marks. Quantification of Contractile Forces Developed by Fibroblasts from Early Stretch Marks (Red Color) and from Healthy Surrounding Skin Using GlasBox^Plus Device. Journal of Cosmetics, Dermatological Sciences and Applications, 7, 177-188. doi: 10.4236/jcdsa.2017.72016.