There is an increasing concern about agriculture’s role in polluting the environment which makes farmers feel guilty about using fertilizers. Fertigation is proposed as a panacea to this dilemma, which by this practice reaffirms the principles of 4Rs which are the right source, at the right rate, right time and right place. The aim of this study was to explore constraints and opportunities for its application in developing countries for environmentally friendly fertilizers application. It is a review of literature from government reports, legislature and published material on fertilization and irrigation initiatives of developing countries which include Rwanda, Nepal, Suriname, Zambia, Panama, Tanzania, Sri Lanka and South Sudan in addition to the case presented of China during the “2016 Environmentally Friendly Fertilizer Production, Application and Demonstration from Developing Countries” training course. The study found that in developing countries there is potential to apply fertigation as a way of environmentally friendly fertilizers application as it has been adopted in China. These opportunities include the following: Abundant natural resources like land and water, less polluted environment, conducive agricultural policies, zero duties levied on imported irrigation equipment. However, a number of limitations also are highlighted including: Lack of investment, lack of infrastructure, lack of information, requires expertise on plant nutrition and management of fertigation system, require soil analysis and proper interpretation which is done by experts. This study provides relevant information for fertigation planning and application in respective developing countries.