Author(s)

Ahmed M. El-Morsy¹, Mohamed S. El-Sayed¹, Hamada S. Abulkhair^1,2*

¹Department of Organic Chemistry, College of Pharmacy, Al-Azhar University, Cairo, Egypt.
²Material and Biomedical Sciences, Zewail City of Science and Technology, Cairo, Egypt.

A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The structures of the new derivatives were confirmed by the spectral data and elemental analyses. The antitumor activity of this series against human breast adenocarcinoma cell line MCF7 was evaluated. Out of twenty new derivatives, ten were revealed mild to moderate activity compared with doxorubicin as a reference antitumor. Among this new series N-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide (13_a) was found the most active one with IC₅₀ equal to 23 μM.

Pyrazolo[3, 4-d]Pyrimidine, Antitumor, Human Breast Adenocarcinoma Cell Line MCF7

El-Morsy, A. , El-Sayed, M. and Abulkhair, H. (2017) Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4-d]Pyrimidine Derivatives. Open Journal of Medicinal Chemistry, 7, 1-17. doi: 10.4236/ojmc.2017.71001.