Author(s)

Ma. de Lourdes Zúñiga-Martínez¹, Yolanda Terán-Figueroa^2*, Laura Escarlet Guerrero-Cruz¹, Ángel Antonio Vértiz-Hernández¹

¹Academic Coordination Altiplano Region, Autonomous University of San Luis Potosi, San Luis Potosi, Mexico.
²Faculty of Nursing and Nutrition, Autonomous University of San Luis Potosi, San Luis Potosi, Mexico.

Objective: To determine the relationship between clinical parameters (HbA_1c) whit metabolic control and deterioration of peripheral arterial perfusion in diabetic patients. Methodology: 108 medical records of patients with type 2 diabetes mellitus were evaluated. We obtained averages of: blood glucose (162.3 ± 73.10 mg/dl), glycated hemoglobin (HbA_1c = 7.64% ± 1.77%), cholesterol (189.28 ± 35.25 mg/dl), triglycerides (189.11 ± 87.76 mg/dl), Systolic Blood Pressure (SBP = 119.69 ± 14.95 mmHg), Diastolic Blood Pressure (DBP = 77.15 ± 9.55 mmHg) and Media Blood Pressure (MBP = 91.36 ± 9.89 mmHg). We correlated variable HbA_1c with vascular injury symptomatology. Results: Correlation was found between sensitivity dysfunction and HbA_1c with a statistical significance of p = 0.01, and a correlation Kendal coefficient w = 0.01, any other parameter of metabolic control was not correlated with symptoms of vascular injury. Conclusion: It is remarkable that the sensitivity dysfunction is a symptom of poorly vascularized lower extremities caused for both functional impairment and structural changes in diabetic patients’ peripheral nerves, even in the preclinical stage of vascular disease. The HbA_1c could also be investigated as a likely sensitivity dysfunction biomarker in DM due to the correlation presented in this study but more studies must be realized.

Protein Glycation, Vascular Disease, HbA_1c, Type 2 Diabetes Mellitus

Zúñiga-Martínez, M. , Terán-Figueroa, Y. , Guerrero-Cruz, L. and Vértiz-Hernández, Á. (2017) Clinical Parameters of Metabolic Control (HbA_1c) and Deterioration of Peripheral Arterial Perfusion in Type 2 Diabetes. Journal of Diabetes Mellitus, 7, 31-39. doi: 10.4236/jdm.2017.71003.