Author(s)

Aldo S. de Oliveira^1*, Inês M. C. Brighente¹, Rafael G. Lund², Luana C. Llanes¹, Ricardo J. Nunes¹, Lizandra C. Bretanha¹, Rosendo Augusto Yunes¹, Pedro H. A. Carvalho², Juliana S. Ribeiro²

¹Department of Chemistry, Center of Physical and Mathematical Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
²Oral Microbiology Laboratory, Faculty of Dentistry, Federal University of Pelotas, Pelotas, Brazil.

This article reports the evaluation of antioxidant and antifungal activity from synthetic naphthoquinones derived from lawsone. The antifungal activity was carried out through the inhibition of exoenzymes produced by Candida albicans. The inhibition of phospholipase and the proteinase production by Candida was similar in all derivatives tested; however, the difference between the enzyme production of the control and test does not show statistical difference in any of the studied strains. Furthermore, the antioxidant activity using DPPH radical-scavenging assay showed an important activity for all naphtoquinone derivatives.

Napthoquinones, Antifungal, Candida albicans, Antioxidant

Oliveira, A. , Brighente, I. , Lund, R. , Llanes, L. , Nunes, R. , Bretanha, L. , Yunes, R. , Carvalho, P. and Ribeiro, J. (2017) Antioxidant and Antifungal Activity of Naphthoquinones Dimeric Derived from Lawsone. Journal of Biosciences and Medicines, 5, 39-48. doi: 10.4236/jbm.2017.52004.