An-Najah National University (ANU), a Palestinian non-governmental public university located in Nablus in the northern part of Palestine, serves 17,807 students with 1020 professors in 11 faculties, and has been striving to integrate technology in its systems to keep up with the global flux of change in all aspects of life. For 10 years An-Najah has pursued the integration of e-learning in residential, blended and fully online delivery. Following a brief summary of the history of An-Najah National University, change management strategies are featured, highlighting specific successful techniques. The case study concludes a description of the change management model that emerged in addition to indicators of a great impact on students’ satisfaction and staff members’ participation ratios.