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Chronological changes in Epstein-Barr virus genome and subsets of peripheral mononuclear cells in a case of HLH

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DOI: 10.4236/ojped.2011.13008    3,724 Downloads   7,061 Views

ABSTRACT

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder characterized by high grade fever, heaptos-plenomegaly, lymphadenopathy and cytopenia in association with hypercytokinemia and macrophage activation. Epstein-Barr virus (EBV) is a common cause of HLH particularly in Asian countries. Although EBV usually infects B cells and causes infectious mononucleosis, it is detected predominantly in CD8+ T cells in EBV-associated HLH. In the present study we found the EBV genome in various lineages of the lymphoid cells including T, B, and natural killer cells in a 14-month-old boy with mild EBV-associated HLH. Furthermore, chronological changes in the copy number of EBV-DNA in each lineage are reported. Profound decrease in the number of peripheral natural killer cells at the early stage could be involved in the development of HLH.

Cite this paper

Ukeba-Terashita, Y. , Saita, Y. , Ito, Y. , Kanegane, H. , Kimura, H. and Kobayashi, I. (2011) Chronological changes in Epstein-Barr virus genome and subsets of peripheral mononuclear cells in a case of HLH. Open Journal of Pediatrics, 1, 30-33. doi: 10.4236/ojped.2011.13008.

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