Author(s)

Jingming Qu^1,2, Xiaohui Zhang^1,2, Xingyue Jia^1,2, Rong Han^1,2

¹School of Life Science, Shanxi Normal University, Linfen, China.
²Higher Education Key Laboratory of Plant Molecular and Environmental Stress Response, Shanxi Normal University, Linfen, China.

Profilin is a small actin-binding protein that is essential in all organisms. While the wheat genome sequence database is not currently available, the exploration of bioinformatics is very important. Therefore, this article predicted the structure and function of profilin in wheat by bioinformatics methods. The amino acid sequence of profilin was searched in GeneBack. While its signal peptides were analyzed through CBS prediction server, the hydrophobicities were analyzed by bioedit software, we used EMBnet server and DNAstar to analyse the transmembrane domains and the B-cell epitopes of the profilin respectively. Finally, the tertiary structure of the protein was predicted through Swiss-Model. This information will help develop rational strategies to improve the component-resolving diagnosis and immunotherapy of profilin allergy.

Wheat, Profilin Allergic, Bioinformatics

Qu, J. , Zhang, X. , Jia, X. and Han, R. (2016) Bioinformatics of Profilin in Wheat. Open Journal of Immunology, 6, 181-188. doi: 10.4236/oji.2016.64017.