Comparison between Two Ethanolic Solutions for 3’-Deoxy-3’-[18F]Fluorothymidine Elution - Advances in Chemical Engineering and Science

ACES > Vol.7 No.1, January 2017

Comparison between Two Ethanolic Solutions for 3’-Deoxy-3’-[¹⁸F]Fluorothymidine Elution ()

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DOI: 10.4236/aces.2017.71003 1,566 Downloads 2,866 Views Citations

Author(s)

Leonardo T. C. Nascimento^*, Marina B. Silveira, Soraya M. Z. M. D. Ferreira, Juliana B. Silva

Affiliation(s)

Centro de Desenvolvimento da Tecnologia Nuclear, CDTN, Belo Horizonte, Brasil.

ABSTRACT

3’-Deoxy-3’-[¹⁸F]Fluorothymidine—[¹⁸F]FLT is a Positron Emission Tomography (PET) tracer which has been used for noninvasive assessment of proliferation activity in several types of cancer. During the past few years, some novel approaches for [¹⁸F]FLT synthesis have been developed, mainly focused on optimization of reaction conditions and purification methods. The present study reports the use of two different eluents in the final step of [¹⁸F]FLT production and the evaluation of its effect on radiochemical yield and product quality. The first eluent evaluated was water: ethanol (90:10, v/v), commercially available, and the second was NaCl 0.9% (saline): ethanol (92:8, v/v). The mean of the corrected radiochemical yields corresponded to 27% ± 7% for elution with water and ethanol and to 23% ± 3% for elution with saline and ethanol, which could indicate that the eluent solutions have similar elution strength. Besides, quality control results were in accordance with the requirements and demonstrated that there was no significant difference between both formulations. Considering that pharmaceutical preparations containing ethanol should be preferentially diluted with saline to avoid hemolysis, the eluent saline:ethanol (92:8, v/v) was chosen for [¹⁸F]FLT extraction and final formulation.

KEYWORDS

[¹⁸F]FLT, Synthesis, Quality Control, Formulation, Elution, Radiopharmaceutical

Share and Cite:

Nascimento, L. , Silveira, M. , Ferreira, S. and Silva, J. (2017) Comparison between Two Ethanolic Solutions for 3’-Deoxy-3’-[¹⁸F]Fluorothymidine Elution. Advances in Chemical Engineering and Science, 7, 23-33. doi: 10.4236/aces.2017.71003.

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