Anticoagulant, Antiplatelet and Antianemic Effects of Citrus paradisi (Grape Fruit) Juice in Rabbits - Pharmacology & Pharmacy

PP > Vol.7 No.10, October 2016

Anticoagulant, Antiplatelet and Antianemic Effects of Citrus paradisi (Grape Fruit) Juice in Rabbits ()

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DOI: 10.4236/pp.2016.710047 2,042 Downloads 5,677 Views Citations

Author(s)

Neelam Mallick¹, Rafeeq Alam Khan^2*, Azra Riaz², Syeda Afroz²

Affiliation(s)

¹Department of Pharmacology, Ziauddin University, Karachi, Pakistan.
²Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

ABSTRACT

Medicinal plants are under continuous analysis worldwide to explore new medication to treat atherosclerosis and cardiovascular diseases. Citrus fruits have displayed utmost antioxidant activity, particularly flavonoids in Citrus paradisi have exhibited strong antioxidant and anti-inflammatory characteristics. This study was intended to examine effects of C. paradisi on blood coagulation and anticoagulation at doses of 0.1, 0.3 and 0.5 ml/kg. Highly significant increase in thrombin time (TT) and substantial decline in fibrinogen (Fb) level was noticed as related to control. There was substantial increase in TT, prothrombin time (PT) and activated partial thromboplastin time (aPTT) and noteworthy decrease in Fb level by warfarin. C. paradisi at 0.3 ml/kg considerably inhibited aggregation of platelet by collagen, adenosine phosphate, arachidonic acid and epinephrine, while there was also substantial rise in Protein C, TAT complex, RBC and hemoglobin concentration. In conclusion, these results suggest that the addition of C. paradisi to the diet of patients at risk of developing cardiovascular events could significantly decrease the morbidity or mortality in these patients due to high contents of phytochemicals like naringin, hesperidin, limonene and other flavonoids.

KEYWORDS

Anticoagulant, Antiplatelet, Antianemic, Grape Fruit

Share and Cite:

Mallick, N. , Alam Khan, R. , Riaz, A. and Afroz, S. (2016) Anticoagulant, Antiplatelet and Antianemic Effects of Citrus paradisi (Grape Fruit) Juice in Rabbits. Pharmacology & Pharmacy, 7, 397-406. doi: 10.4236/pp.2016.710047.

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