MicroRNAs Play Significant Roles in Pathogenesis of HBV-Related Diseases - Journal of Biomedical Science and Engineering

JBiSE > Vol.9 No.10, September 2016

MicroRNAs Play Significant Roles in Pathogenesis of HBV-Related Diseases ()

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Download as PDF (Size: 379KB) PP. 78-89

DOI: 10.4236/jbise.2016.910B011 1,614 Downloads 2,451 Views Citations

Author(s)

Gaoyun Chen¹, Min Liu¹, Zhigang Jiang¹, Mengbin Yu¹, Sichen Wei²

Affiliation(s)

¹Institute of Chemical Defense, Beijing, China.
²Faculty of Science of Beijing University of Chemical Technology, Beijing, China.

ABSTRACT

MicroRNAs (miRNAs) comprise an important class of small (about 22 nt) conserved nonprotein-coding RNAs that specifically regulate cellular gene expression at the post-transcriptional level. Increasing researches showed that miRNAs have emerged as critical regulators involved in diverse physiological and pathological processes, in-cluding such as proliferation, differentiation and development, apoptosis and patho-gen-host interactions. This review summarizes the crucial roles of miRNAs in replica-tion of the Hepatitis B virus (HBV) and the mechanism underlying dysregulation of miRNAs in HBV-associated diseases. miRNAs are emerged as essential regulators of HBV replication and pathogenesis. To a certain extent, miRNA is a new promising biomarker and useful strategy for diagnosis of HBV-related diseases.

KEYWORDS

MicroRNA, HBV, Expression, Regulation, Biomarker

Share and Cite:

Chen, G. , Liu, M. , Jiang, Z. , Yu, M. and Wei, S. (2016) MicroRNAs Play Significant Roles in Pathogenesis of HBV-Related Diseases. Journal of Biomedical Science and Engineering, 9, 78-89. doi: 10.4236/jbise.2016.910B011.

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